🌿 Low Dose Naltrexone (LDN) for Multiple Sclerosis & Autoimmune Conditions
By Dr. Devin Wilson, ND | Valley Integrative Health
What Is LDN?
Low Dose Naltrexone (LDN) is a safe, affordable, and well-researched therapy that works by gently modulating the immune system.
At standard doses, naltrexone is used to treat addiction. But in low doses—typically 1.5–4.5 mg—it acts very differently, helping calm overactive immune responses and reduce inflammation throughout the body.
How LDN Works
LDN temporarily blocks opioid receptors for a few hours each night. This mild, short-term “block” stimulates the body to increase production of its own endorphins—our natural pain-relieving and immune-balancing chemicals.
This rise in endorphins helps:
Regulate immune activity (reducing autoimmunity and inflammation)
Support healthy T-cell balance
Reduce nerve pain and fatigue
Improve mood and sleep quality
LDN and Multiple Sclerosis (MS)
For individuals with MS, LDN has shown promise in:
Decreasing fatigue and muscle spasms
Improving mobility and overall well-being
Reducing pain and enhancing quality of life
While LDN is not a cure, it can be an important adjunct therapy—helping the body reduce inflammatory responses that damage the myelin sheath (the protective coating around nerves).
LDN for Other Autoimmune Conditions
LDN has been studied and clinically used in a wide range of autoimmune and inflammatory disorders, including:
Hashimoto’s Thyroiditis
Rheumatoid Arthritis
Lupus (SLE)
Psoriasis and Eczema
Crohn’s Disease and Ulcerative Colitis
Fibromyalgia
Lyme Disease and Mold Illness
Long COVID and Chronic Fatigue Syndrome
Many patients report improved energy, reduced pain, and better immune balance after several months of consistent use.
Safety and Tolerability
LDN is generally very well tolerated.
Possible mild side effects—such as vivid dreams, mild sleep disturbance, or temporary nausea—are usually short-lived and resolve as the body adjusts.
LDN does not suppress the immune system, and it has no known long-term toxicity at low doses.
Integrative Approach
At Valley Integrative Health, we take a comprehensive approach to autoimmune care—combining LDN with:
Nutritional and lifestyle strategies
Functional lab testing to identify root causes
Gut and liver support for optimal detoxification
Personalized supplement and peptide protocols
This whole-body approach helps restore immune regulation and resilience over time.
Is LDN Right for You?
If you’re living with Multiple Sclerosis or another autoimmune condition, LDN may be a gentle yet powerful addition to your healing plan.
Schedule a free 15-minute discovery call to learn how LDN can fit into your personalized treatment plan.