Understanding MARCoNS, Mold Illness & Chronic Sinusitis
How a Compounded Nasal Spray Can Help You Finally Feel Better
If you struggle with ongoing sinus issues—congestion, pressure, post-nasal drip, headaches, or recurrent infections—you’re not alone. For many patients with mold exposure or Chronic Inflammatory Response Syndrome (CIRS), the root cause is something called MARCoNS.
What Is MARCoNS?
MARCoNS stands for Multiple Antibiotic-Resistant Coagulase-Negative Staph—a type of stubborn bacteria that lives deep in the sinuses.
It doesn’t usually cause severe infections, but it keeps the sinuses inflamed, disrupts the immune system, and makes it harder for the body to recover from mold-related illness.
Patients with MARCoNS often experience:
Chronic congestion
Sinus pressure or pain
Post-nasal drip
Ear fullness
Fatigue and brain fog
Worsening symptoms after mold exposure
Because MARCoNS creates biofilms (a protective layer), it can be extremely difficult to clear with standard sinus treatments.
Why Mold Illness and MARCoNS Go Together
People with mold exposure or CIRS often have an overactive, exhausted immune system. This makes it easier for MARCoNS to take hold and harder for the body to clear it.
MARCoNS can then:
Prolong sinus inflammation
Trigger worsening fatigue and cognitive symptoms
Interfere with detox pathways
Keep the inflammation cycle going
This is why treating MARCoNS is often a key step in mold recovery.
How a Compounded Nasal Spray Helps
At Valley Integrative Health, we use custom-formulated compounded nasal sprays designed to:
1. Break up biofilms
Special ingredients dissolve the bacterial biofilm so the active medication can reach the source of infection.
2. Reduce inflammation in the sinus passages
This helps relieve congestion, pressure, and headaches.
3. Target the MARCoNS bacteria directly
Depending on your lab results, the spray may include:
Antimicrobial agents
Biofilm disruptors
Anti-inflammatory ingredients
4. Support long-term healing
By clearing MARCoNS, the immune system can reset, which often leads to better energy, clearer thinking, and fewer mold-related symptoms.
What Treatment Looks Like
You complete a simple nasal swab test to check for MARCoNS.
If positive, we prescribe a custom compounded nasal spray.
Most patients use the spray 2–3 times per day for several weeks.
As the sinus passages heal, patients often notice improvements in congestion, sleep, headaches, and mold-related symptoms.
The Bottom Line
If you’re dealing with persistent sinus symptoms, fatigue, or mold illness that just won’t improve, MARCoNS may be part of the picture. A targeted compounded nasal spray can safely and effectively help clear the infection so your body can finally heal.
Contact Valley Integrative Health Today.
Devin Wilson, ND is a licensed Naturopathic Doctor and Owner of Valley Integrative Health, LLC in Ashland, Oregon. With over a decade of clinical experience including 2 years of training with a John’s Hopkin’s/Yale Medical Doctor, Dr. Wilson combines naturopathic and modern medicine along with cutting-edge therapies. His enduring goal is to help people re-establish, maintain and optimize their health using a patient-centered and holistic approach.